Expert Voices

Pregnancy in space: Studying stem cells in zero gravity may determine whether it's safe

astronaut holding a long structure over cloudy Earth
Weightlessness affects how our cells develop and divide. (Image credit: MarcelClemens/Shutterstock)

This article was originally published at The Conversation. (opens in new tab) The publication contributed the article to Space.com's Expert Voices: Op-Ed & Insights.

Joanna Bridger (opens in new tab), Director of the Centre for Genome Engineering and Maintenance (CenGEM), Professor of Genome Organisation, Brunel University London
Emmanouil Karteris (opens in new tab), Reader in Biomedical Sciences, Brunel University London

Space is a hostile, extreme environment. It's only a matter of time before ordinary people are exposed to this environment, either by engaging in space tourism or by joining self-sustaining colonies (opens in new tab) far away from Earth.

To this end, there needs to be a much better understanding of how the environmental dangers of space will affect the biology of our cells, tissues, organs and cognition. Crucially for future space colonies, we need to know whether we can easily reproduce in environments other than those found on Earth.

The effects of radiation on our cells, producing DNA damage, are well documented (opens in new tab). What's less clear is how lower levels of gravity, what scientists call microgravity (opens in new tab), will affect the mechanisms and rhythms taking place within our cells.

Scientists are only just beginning to investigate how activity in our cells might be affected by exposure to microgravity. Crucially, experiments on embryonic stem cells, and models of how embryos develop (opens in new tab) in their first few weeks in space, will help us determine whether it's possible for humans to produce offspring in the extraplanetary colonies of the future.

Related: What does space do to the human body? 29 studies investigate the effects of exploration

Cosmic conception

The ability to reproduce in space has been assessed in a few animals (opens in new tab), including insects, amphibians, fish, reptiles, birds and rodents. They have found that it's certainly possible for organisms such as fish, frogs and geckos (opens in new tab) to produce fertilized eggs during spaceflight that can live and reproduce on Earth.

But the picture is more complicated in mammals. A study of mice, for instance, found that their estrous cycle (opens in new tab), part of the reproductive cycle, was disrupted by exposure to microgravity (opens in new tab). Another study found that exposure to microgravity caused negative neurological alterations (opens in new tab) in rats. Hypothetically, these effects could also be transmitted to subsequent generations.

This likely happens because our cells did not evolve to work in microgravity. They evolved over millions of years on Earth, in its unique gravitational field. Earth's gravity is part of what anchors and exerts physical force on our tissues, our cells, and our intracellular contents, helping to control specific movements within cells. The study of this is called mechanobiology (opens in new tab).

Cells are busy with microbiological activity. (Image credit: Christoph Burgstedt/Shutterstock)

The division of cells and the movement of genes and chromosomes within them, which is crucial to the development of a fetus, also works with and against the force of gravity as we know it on Earth. It follows that systems evolved to work perfectly in Earth's gravity may be affected when the force of gravity changes.

Fetal position

When an embryo first starts to divide, in a process called cleavage (opens in new tab), the rate of division can be faster at one end of the embryo than the other. Gravity plays a role here, determining the position of the very first building blocks in a human life.

Gravity also helps to establish the correct body plan of a fetus, ensuring the right cells develop in the right places in the right numbers and in the right spatial orientation.

Researchers have investigated whether embryonic stem cells, which are "pluripotent (opens in new tab)" and can develop into all cells of the body, are affected by microgravity. At present, there is some evidence (opens in new tab) that when rodent embryonic stem cells are subjected to microgravity, their ability to become the desired cell types may be impacted.

It is also possible to produce pluripotent human stem cells from normal mature cells of our bodies, which are called induced pluripotent stem cells (opens in new tab). These have also been studied under microgravity, with experiments on Earth finding that induced stem cells proliferate faster (opens in new tab) in simulated microgravity. Two batches of these stem cells are currently on the International Space Station to see whether these results can be replicated in space.

The International Space Station regularly plays host to scientific experiments. (Image credit: Vadim Sadovski/Shutterstock)

If adult stem cells do proliferate faster in space, it could open the door for commercial stem cell manufacturers (opens in new tab) to produce these cells in orbit, seeing as it's difficult to culture enough stem cells on Earth to treat degenerative diseases with stem cell therapies (opens in new tab).

Gravitational field

Besides normal cellular processes, it's also unclear how fertilization, hormone production, lactation and even birth itself will be affected by exposure to microgravity.

It seems that short-term exposure to microgravity, of perhaps half an hour, will probably not have too much of an effect on our cells. But longer exposures of days or weeks are likely to have an effect. This is not taking into account the effect of radiation on our cells and DNA, but we already know how to protect against radiation.

Scientists are looking at two ways to protect against the adverse effects of microgravity on our biology: intervention at the cellular level, using drugs or nanotechnology, and intervention on the environmental level, by simulating Earth's gravity in spacecraft or off-world colonies. Both fields of study are in their early stages.

Still, studying stem cells in space provides a valuable window into how pregnancy could work, or not work, when we're outside Earth's gravitational field. For now, those fortunate enough to go to space might do well to avoid attempting to conceive before, during or directly after a space flight.

This article is republished from The Conversation (opens in new tab) under a Creative Commons license. Read the original article (opens in new tab).

Follow all of the Expert Voices issues and debates — and become part of the discussion — on Facebook and Twitter. The views expressed are those of the author and do not necessarily reflect the views of the publisher.

Join our Space Forums to keep talking space on the latest missions, night sky and more! And if you have a news tip, correction or comment, let us know at: community@space.com.

Joanna Bridger
Director of the Centre for Genome Engineering and Maintenance (CenGEM), Professor of Genome Organisation, Brunel University London

My main research interest has been for many years the functional organization of our genomes within its controlled environment the cell nucleus. Our genome distributed into individual chromosome territories is anchored and regulated by the proteinaceous scaffolding within the nucleus called the nucleoskeleton. My research group has for the last 20 or so years been investigating the relationship of the genome with these various structures that make up the nucleoskeleton. This we have pursued through various model organisms such as pigs and snails, in various diseases where the nucleoskeleton is compromised including degenerative tissue diseases the laminopathies, the premature aging disease Hutchinson-Gilford Progeria Syndrome, breast and ovarian cancer and normal aging and specific cell types such as embryonic and adult stem cells, fibroblasts, myocytes and adipocytes. We are currently investigating mechanisms and compounds that can correct the issues with the nucleoskeleton in these diseases and in old cells to restore normal genome function.
We are also interested in the mechanobiology of the cell nucleus and study nuclear motor proteins that actively move genes and chromosomes around in response to external signals such as stress and infection. This interest in active movement of the genome around the nucleus has led us to being intrigued by the effects of microgravity on internal cellular movements, embryo development and aging and how to mitigate its effects in space travel and use it for restoring compromised genome behavior.