This Israeli startup's sci-fi 'headset' will map brain changes in space on private Ax-1 mission

A novel Brain.Space headset will map how the brain changes during spaceflight during the Ax-1 private mission to the International Space Station by Axiom Space.
A novel Brain.Space headset will map how the brain changes during spaceflight during the Ax-1 private mission to the International Space Station by Axiom Space. (Image credit: Brain.Space)

A brain 'headset' aims to provide a high-resolution view of neural changes that happen in the brain while space, and it will fly aboard Axiom Space's first crewed launch, Ax-1.

If all goes to plan, the brain experiment, which comes from Israel-based startup Brain.Space, will launch aboard a SpaceX Crew Dragon vehicle on April 6 along with the four private astronauts the Ax-1 mission. The crew, whose flight was booked by Axiom Space, will embark on a 10-day excursion which will include eight days of living and working aboard the International Space Station.

The headset and associated hardware will be tested aboard the ISS, Brain.Space said on their website. The experiment will also return to Earth with the Ax-1 crew.

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The company says that their examination of the brain will be unique, as, according to them, to-date, "there is currently no high-quality longitudinal data regarding the neural changes in prolonged space missions," their website states.

By obtaining and studying this information, the company aims to gain more insight into how the brain adapts in space, which is an environment full of challenges like radiation, microgravity and isolation. Learning about the "day-to-day plastic changes" of the brain, the company states on its website. The company terms that these adaptations, could help future spaceflyers get more comfortable in orbit.

Studies of neurons, or nervous system cells that include brain cells, have been performed in space before. But, on its website, Brain.Space says that these studies were performed using gel-based systems that assess electrical activity at low resolution, known as EEGs (or electroencephalogram.)

The experiments, the company noted, "were complex to set up in microgravity and only focused on simple brain activity measurements." Their EEG brain headset, Brain.Space said, will simplify the setup and give far more detail as to how the brain behaves.

The experimentation with this headset will monitor brain activity, along with how the brain assesses and uses knowledge in space, also called cognitive performance. Besides forming adaptations for future space flyers, the headset should provide some metrics to assess the health of brains in space, which may flow to more studies in the future.

The researchers aim to collect 15-minute EEG recordings twice a day across eight days. Videos will flow to the company in Tel Aviv, Israel for troubleshooting and assistance, and the data will then be analyzed at both the company and its research partner, Ben-Gurion University in Beersheba, Israel.

The tasks to be performed with the headset include looking at the "resting state" of the brain in space, and looking at the brain while the research subject looks at a "visual oddball" (a waveform). The startup says they hope to be able to use this information to help individuals on Earth with brain disorders, such as sleep problems or schizophrenia.

It is unclear how many crew members will participate in the experiment, which is part of the larger set of Ramon Foundation experiments going to space with crewmember Eytan Stibbe. (Brain.Space says all of the crew has been trained to operate the headset.)

Stibbe was a long-time friend of Israeli astronaut Ilan Ramon, who died aboard space shuttle Columbia in 2003; Stibbe co-created the foundation in part to honor Ramon's legacy. Stibbe will be the second Israeli astronaut to reach space, after Ramon.

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Elizabeth Howell
Staff Writer, Spaceflight

Elizabeth Howell (she/her), Ph.D., is a staff writer in the spaceflight channel since 2022 covering diversity, education and gaming as well. She was contributing writer for for 10 years before joining full-time. Elizabeth's reporting includes multiple exclusives with the White House and Office of the Vice-President of the United States, an exclusive conversation with aspiring space tourist (and NSYNC bassist) Lance Bass, speaking several times with the International Space Station, witnessing five human spaceflight launches on two continents, flying parabolic, working inside a spacesuit, and participating in a simulated Mars mission. Her latest book, "Why Am I Taller?", is co-written with astronaut Dave Williams. Elizabeth holds a Ph.D. and M.Sc. in Space Studies from the University of North Dakota, a Bachelor of Journalism from Canada's Carleton University and a Bachelor of History from Canada's Athabasca University. Elizabeth is also a post-secondary instructor in communications and science at several institutions since 2015; her experience includes developing and teaching an astronomy course at Canada's Algonquin College (with Indigenous content as well) to more than 1,000 students since 2020. Elizabeth first got interested in space after watching the movie Apollo 13 in 1996, and still wants to be an astronaut someday. Mastodon: