Wearing Russian partial pressure flight suits, cosmonauts Vladimir Dezhurov and Mikhail Turin will climb aboard a Soyuz lifeboat along with station skipper Frank Culbertson, temporarily leaving the outpost in the hands of ground controllers in Moscow and Houston.
With Dezhurov at the controllers, the bug-shaped spacecraft will back away from a port on the stations Russian Zarya space tug about 6:48 a.m. EDT (1048 GMT).
The trio then will take a short ride over to a port on the outposts newly installed Russian airlock, which doubles as an extra parking place for Soyuz crew transport vehicles and Progress cargo carriers.
The 20-minute move, which will be broadcast live on NASA TV, is being carried out to clear the Zarya port for a visiting Soyuz crew now scheduled to launch Sunday from Baikonur Cosmodrome in Kazakhstan.
Cosmonauts Victor Afanasyev and Konstantin Kozeev, flying with French astronaut Claudie Haignere, will deliver a new Soyuz to the station next Tuesday and then return to Earth Oct. 30 in the lifeboat now at the outpost.
Russian Soyuz spacecraft have an on-orbit life of about six months and are replaced at the outpost twice each year.
Launched in August, Culbertson and his cosmonaut colleagues are in the midst of a four-month research tour aboard the international station. The trio is scheduled to return to Earth Dec. 10 aboard NASAs shuttle Endeavour.